Table 2.
Drug-gene interaction database for candidate genes
| Gene | Drug | CFB | CFCT | DB | GPI | PG | TALC | TE | TT | TC | #of DB | # of PMID | Sum score (DB+PMID) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BCL2 | PACLITAXEL | - | TRUE | TRUE | - | - | - | TRUE | - | TRUE | 4 | 5 | 9 |
| BCL2 | DOCETAXEL | - | - | TRUE | - | - | - | - | - | TRUE | 2 | 6 | 8 |
| BCL2 | RASAGILINE | - | - | TRUE | - | - | - | - | - | - | 1 | 5 | 6 |
| BCL2 | OBLIMERSEN | - | - | - | - | - | TRUE | - | TRUE | TRUE | 3 | 0 | 3 |
| FPR1 | NEDOCROMIL | - | - | TRUE | - | - | - | - | - | - | 1 | 3 | 4 |
| NR1H4 | CHENODEOXYCHOLIC ACID | - | - | TRUE | TRUE | - | - | - | - | - | 2 | 2 | 4 |
| NR1H4 | FEXARAMINE | - | - | TRUE | TRUE | - | - | - | - | - | 2 | 2 | 4 |
| TERT | GV1001 | - | - | TRUE | - | - | - | - | - | TRUE | 2 | 1 | 3 |
| TNF | THALIDOMIDE | - | - | TRUE | - | - | - | TRUE | TRUE | TRUE | 4 | 7 | 11 |
| TNF | AMRINONE | - | - | TRUE | - | - | - | - | - | - | 1 | 5 | 6 |
| TNF | CHLOROQUINE | - | - | TRUE | - | - | - | - | - | - | 1 | 5 | 6 |
| TNF | CLENBUTEROL | - | - | TRUE | - | - | - | - | - | - | 1 | 5 | 6 |
| TNF | PSEUDOEPHEDRINE | - | - | TRUE | - | - | - | - | - | - | 1 | 2 | 3 |
CFB: Clearity Foundation Biomarkers, CFCT: Clearity Foundation Clinical Trial, DB: Drugbank, GPI: Guide to Pharmacology Interactions Version: 04-March-2015, PG: PharmGKB - The Pharmacogenomics Knowledgebase, TALC: Targeted Agents in Lung Cancer, TE: Trends in the exploitation of novel drug targets, TT: Therapeutic Target Database, Version 4.3.02, TC: The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication.