Fig. 4.

Effect of compounds 15 and 16 on human dermal fibroblasts (hDFs). (A) Cell photography and (B) cell proliferation after treatment with S-methylmethionine sulfonium (SMMS), compound 15, and compound 16 (10 μM). Compounds 15 and 16 increased hDF proliferation in a time-dependent manner. ^$control vs. SMMS; ^#SMMS vs. compound 15 or 16; ^*control vs. compound 15 or 16. ^$p<0.05, ^$$p<0.01; ^#p<0.05, ^##p<0.01, ^###p<0.001; ^*p<0.05, ^**p<0.01, ^***p<0.001; n=3. All error bars indicate SEM. (C, D) Compounds 15 and 16 increased hDF proliferation in a dose-dependent manner. ^**p<0.01, n=3. All error bars indicate SEM.