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. 2017 Nov 13;26(3):306–312. doi: 10.4062/biomolther.2017.109

Fig. 5.

Fig. 5.

Effect of compounds 15 and 16 on human dermal fibroblasts (hDFs). (A) Compound 15 recovered the reduced survival of hDFs following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. (B) Compound 16 recovered the reduced survival of hDFs following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. (C, D) Compounds 15 and 16 recovered the reduced proliferation index (% of BrdU+ cells) of hDFs following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. #control vs. (−); *(−) vs. compound 15 or 16. ***p<0.001, ###p<0.001; n=5–8. All error bars indicate SEM. (E–G) Compounds 15 and 16 restored the downregulated expression of collagen type I mRNA (E) and upregulated expression of MMP-1 and MMP-2 mRNAs (F, G) following UVB irradiation in hDFs. **p<0.01, n=3. All error bars indicate SEM.