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. 2017 Nov 13;26(3):306–312. doi: 10.4062/biomolther.2017.109

Fig. 6.

Fig. 6.

Effect of compounds 15 and 16 in an immortalized human keratinocyte cell line (HaCaT). (A) Compound 15 did not increase HaCaT cell proliferation. (B) Compound 16 increased HaCaT cell proliferation in a dose-dependent manner. (C) Compound 15 recovered the reduced survival of HaCaT following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. (D) Compound 16 recovered the reduced survival of HaCaT following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. **p<0.01, n=3. All error bars indicate SEM. (E, F) Compounds 15 and 16 recovered the reduced proliferation index (% of BrdU+ cells) of HaCaT cells following UVB irradiation (120 mJ/cm2) in a dose-dependent manner. #control vs. (−); *(−) vs. compound 15 or 16. *p<0.05, **p<0.01, ***p<0.001; ###p<0.001; n=4–5. All error bars indicate SEM.