Table 1. Statistical significance of chromosomal localization data in Figure 4.

n₁ and n₂ denote total number of scored loci in cells from two biological replicates (independent strains). P values, from two-tailed Student’s t-tests, indicate the significance of the difference between the observed number of loci in Zone one and the expected random distribution.

Locus genotype	Early/Mid-s	Late S/G
Tel 1L WT	n1 = 112,, n2 = 93 p<0.000001	n1 = 151, n2 = 180 p<0.000001
Tel 1L bqt4Δ	n1 = 110, n2 = 103 p<0.000001	n1 = 143, n2 = 112 p=0.00986
Tel 1L lem2 Δ	n1 = 110, n2 = 86 p<0.000001	n1 = 96, n2 = 160 p<0.000001
mat WT	n1 = 55, n2 = 49 p=5.0 × 10−5	n1 = 85, n2 = 95 p=1.0 × 10−5
mat bqt4Δ	n1 = 70, n2 = 52 p=0.79551	n1 = 91, n2 = 90 p<0.0001
cut3 WT	n1 = 86, n2 = 73 p=0.0459	n1 = 57, n2 = 113 p=0.97412
cut3 bqt4Δ	n1 = 94, n2 = 90 p=0.99545	n1 = 78, n2 = 125 p=0.99801
Taz1 WT	n1 = 51, n2 = 74 p<0.000001	n1 = 85, n2 = 87 p<0.000001
Taz1 bqt4Δ	n1 = 67, n2 = 93 p<0.000001	n1 = 88, n2 = 86 p=5.0 × 10−5
Pot1 WT	n1 = 79, n2 = 65 p<0.000001	n1 = 54, n2 = 68 p<0.000001
Pot1 bqt4Δ	n1 = 64, n2 = 96 p<0.000001	n1 = 59, n2 = 81 p=0.0293
Pot1 taz1Δ	n1 = 60, n2 = 63 p<0.000001	n1 = 88, n2 = 96 p<0.000001
Pot1 taz1Δ bqt4Δ	n1 = 65, n2 = 100 p=0.00025	n1 = 64, n2 = 149 p=2.0 × 10−5
mat swi6Δ	n1 = 72, n2 = 60 p=1.0 × 10−5	n1 = 103, n2 = 120 p=2.0 × 10−5
mat swi6Δ bqt4Δ	n1 = 77, n2 = 75 p=0.0002	n1 = 100, n2 = 59 p=0.0459