Fig. 6. 5-HT3A-positive fibers are found in some brainstem regions where CGRP immunoreactivity is also found within the nTS and adjacent DMSp5.
For each image-drawing pair: Left: photomicrographs of 5-HT3A GFP (green) and CGRP (magenta) immunoreactivity. The white dotted line demarcates the boundary of the nTS. DMSP5: dorsomedial nucleus of the descending trigeminal complex. Right: Spatial distribution of CGRP and 5-HT3A labeled pixels that are 2X standard deviation of background (identified using a customized MATLAB program). Labeled pixels that overlap are shown as black. The solid black outline indicates the boundaries of the tissue; whereas the black dotted line demarcates the boundary of the nTS.