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. Author manuscript; available in PMC: 2018 May 3.
Published in final edited form as: Nature. 2017 Nov 1;551(7679):247–250. doi: 10.1038/nature24297

Extended Data Figure 2. Additional data demonstrating that GPX4 inhibition causes ferroptosis in persister cells.

Extended Data Figure 2

A375 persister cells were treated with a, RSL3 or b, ML210 and ferroptosis rescue compounds for three days. c, PC9 persister cells were treated with RSL3 or ML210 and ferroptosis rescue compounds for three days. d, Relative concentration of total labile iron in BT474 parental and persister cells. Data are plotted as means and error bars represent standard deviation. a-d, n = 2 biologically independent samples. From two-tailed t tests, *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, P > 0.05. All data are representative of two separate experiments.