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. Author manuscript; available in PMC: 2018 May 3.
Published in final edited form as: Nature. 2017 Nov 1;551(7679):247–250. doi: 10.1038/nature24297

Figure 1. RNAseq and small-molecule screen in drug-tolerant persister cells.

Figure 1

a, A small fraction of BT474 cells enter into a reversible, quiescent drug-tolerant persister state in response to nine or more days of treatment with 2 μM lapatinib. Scale bars indicate 100 μm. b, Small-molecule inhibitor screen in which prederived BT474 persister cells were treated with 1 μM small-molecule inhibitors while maintained in 2 μM lapatinib. c, Small-molecule inhibitor counter-screen in parental BT474 cells. a is representative of two independent experiments. b, c, n = 1 biologically independent sample from a single screening experiment.