Table 1.
Clinical characteristics according to the presence of CMBs.
| Any CMBs |
Deep or infratentorial CMBs |
Lobar CMBs |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Present |
Absent |
p value | Present |
Absent |
p value | Present |
Absent |
p value | |
| (n = 13) | (n = 115) | (n = 7) | (n = 121) | (n = 7) | (n = 121) | ||||
| Age, y | 72.3 (8.3) | 63.5 (9.5) | < 0.01 | 75.0 (7.3) | 63.8 (9.5) | < 0.01 | 70.0 (8.5) | 64.1 (9.7) | 0.12 |
| Male | 5 (38.5) | 51 (44.4) | 0.69 | 4 (57.1) | 52 (43.0) | 0.46 | 2 (28.6) | 54 (44.6) | 0.41 |
| BMI, kg/m2 | 20.7 (19.8–24.4) | 21.1 (18.5–24.0) | 0.59 | 20.5 (18.1–20.7) | 21.2 (18.5–24.1) | 0.37 | 23.5 (19.8–24.7) | 20.9 (18.5–23.9) | 0.15 |
| eGFR, mL/min per 1.73 m2 | 88.4 (25.6) | 88.3 (21.3) | 0.99 | 95.7 (29.6) | 87.9 (21.2) | 0.36 | 85.6 (23.0) | 88.5 (21.7) | 0.73 |
| LDL-cholesterol, mg/dL | 108.9 (32.3) | 106.5 (27.7) | 0.77 | 98.3 (26.9) | 107.3 (28.2) | 0.41 | 118.0 (33.9) | 106.1 (27.7) | 0.28 |
| HDL-cholesterol, mg/dL | 58.3 (17.5) | 60.7 (12.9) | 0.57 | 55.3 (14.0) | 60.7 (13.3) | 0.34 | 58.6 (20.9) | 60.5 (12.8) | 0.71 |
| HbA1c, % | 5.8 (5.6–6.1) | 5.7 (5.5–6.0) | 0.43 | 5.6 (5.4–6.1) | 5.7 (5.5–6.0) | 0.57 | 5.9 (5.7–6.1) | 5.7 (5.5–6.0) | 0.26 |
| Hypertension | 5 (38.5) | 26 (22.6) | 0.21 | 3 (42.9) | 28 (23.1) | 0.24 | 2 (28.6) | 29 (24.0) | 0.78 |
| Diabetes mellitus | 2 (15.4) | 10 (8.8) | 0.44 | 2 (28.6) | 10 (8.3) | 0.08 | 0 (0) | 12 (10.0) | 0.38 |
| Smoking status | |||||||||
| Non-smoker | 10 (76.9) | 79 (68.7) | 0.54 | 4 (57.1) | 85 (70.3) | 0.35 | 6 (85.7) | 83 (68.6) | 0.58 |
| Ex-smoker | 3 (23.1) | 26 (22.6) | 3 (42.9) | 26 (21.5) | 1 (14.3) | 28 (23.1) | |||
| Current smoker | 0 (0) | 10 (8.7) | 0 (0) | 10 (8.3) | 0 (0) | 10 (8.3) | |||
| History of stroke | 1 (7.7) | 3 (2.6) | 0.32 | 1 (14.3) | 3 (2.5) | 0.08 | 0 (0) | 4 (3.3) | 0.63 |
| Antiplatelet | 3 (23.1) | 6 (5.2) | 0.02 | 1 (14.3) | 8 (6.6) | 0.44 | 2 (28.6) | 7 (5.8) | 0.02 |
| Anticoagulant | 0 (0) | 0 (0) | – | 0 (0) | 0 (0) | – | 0 (0) | 0 (0) | – |
BMI, body mass index; CAD, coronary artery disease; CMBs, cerebral microbleeds; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein. Values are number (%), mean (standard deviation), or median (interquartile range), as appropriate.