Table 2.
Clinical characteristics according to postural blood pressure abnormalities.
| OH |
SH |
|||||
|---|---|---|---|---|---|---|
| Present |
Absent |
p value | Present |
Absent |
p value | |
| (n = 60) | (n = 68) | (n = 20) | (n = 108) | |||
| Age, y | 67.1 (8.8) | 62.0 (9.9) | < 0.01 | 68.6 (10.9) | 63.6 (9.4) | 0.04 |
| Male | 26 (43.3) | 30 (44.1) | 0.93 | 12 (60.0) | 44 (40.7) | 0.11 |
| Disease duration, y | 10 (6.3–15) | 10 (6–14) | 0.81 | 10 (6.3–14.8) | 9 (6–15.8) | 0.85 |
| Hoehn and Yahr stage | 3.1 (0.9) | 2.8 (0.8) | 0.04 | 3.4 (0.9) | 2.9 (0.8) | 0.01 |
| Hypertension | 13 (21.7) | 18 (26.5) | 0.53 | 11 (55.0) | 20 (18.5) | < 0.01 |
| Diabetes mellitus | 6 (10.2) | 6 (8.8) | 0.80 | 4 (21.1) | 8 (7.4) | 0.06 |
| Antihypertensive | 11 (18.3) | 16 (23.5) | 0.47 | 7 (35.0) | 20 (18.5) | 0.10 |
| ARB | 6 (10.0) | 9 (13.2) | 0.57 | 3 (15.0) | 12 (11.1) | 0.62 |
| Ca channel blockers | 4 (6.7) | 10 (14.7) | 0.15 | 4 (20.0) | 10 (9.3) | 0.16 |
| β-blockers | 1 (1.7) | 2 (2.9) | 0.63 | 2 (10.0) | 1 (0.9) | 0.02 |
| Diuretic | 4 (6.7) | 0 (0) | 0.03 | 1 (5.0) | 3 (2.8) | 0.60 |
| Antihypotensive | 6 (10.0) | 4 (5.9) | 0.39 | 1 (5.0) | 9 (8.3) | 0.61 |
| Midodrine | 0 (0) | 1 (1.5) | 0.35 | 0 (0) | 1 (0.9) | 0.67 |
| Droxidopa | 6 (10.0) | 3 (4.4) | 0.22 | 1 (5.0) | 8 (7.4) | 0.70 |
| LED, mg | 850 (721–1100) | 910 (604–1248) | 0.91 | 769 (596–917) | 922 (705–1129) | 0.06 |
| Supine SBP, mm Hg | 123.8 (21.4) | 112.9 (16.6) | < 0.01 | 152.2 (16.7) | 111.7 (12.3) | < 0.01 |
| Supine DBP, mm Hg | 72.3 (11.7) | 67.9 (11.3) | 0.03 | 85.0 (13.2) | 67.1 (9.0) | < 0.01 |
| ΔSBP, mm Hg | 32.5 (19.9) | 3.8 (10.8) | < 0.01 | 39.0 (29.6) | 13.2 (16.7) | < 0.01 |
| ΔDBP, mm Hg | 15.3 (10.3) | − 2.3 (6.9) | < 0.01 | 13.5 (14.8) | 4.5 (11.4) | < 0.01 |
| OH | 60 (100) | 0 (0) | – | 16 (80.0) | 44 (40.7) | < 0.01 |
| SH | 16 (26.7) | 4 (5.9) | < 0.01 | 20 (100) | 0 (0) | – |
| 24-hour SBP, mm Hg | 118.9 (11.8) | 112.3 (11.7) | < 0.01 | 126.3 (11.9) | 113.3 (11.1) | < 0.01 |
| 24-hour DBP, mm Hg | 78.3 (9.1) | 73.5 (7.1) | < 0.01 | 80.4 (10.5) | 74.9 (7.7) | < 0.01 |
| Daytime SBP, mm Hg | 120.3 (12.0) | 114.0 (11.4) | < 0.01 | 126.9 (12.0) | 115.1 (11.2) | < 0.01 |
| Daytime DBP, mm Hg | 80.6 (9.6) | 75.9 (7.8) | < 0.01 | 82.3 (10.5) | 77.3 (8.4) | 0.02 |
| Nighttime SBP, mm Hg | 117.8 (15.4) | 109.6 (14.7) | < 0.01 | 126.4 (14.9) | 111.0 (14.5) | < 0.01 |
| Nighttime DBP, mm Hg | 75.2 (11.0) | 69.7 (7.9) | < 0.01 | 77.8 (12.5) | 71.2 (8.9) | < 0.01 |
| NH | 40 (66.7) | 40 (58.8) | 0.36 | 16 (80.0) | 64 (59.3) | 0.08 |
| Non-dipping | 47 (78.3) | 49 (72.1) | 0.41 | 17 (85.0) | 79 (73.2) | 0.26 |
ARB, angiotensin-receptor blockers; DBP, diastolic blood pressure; LED, levodopa equivalent dose; NH, nocturnal hypertension; OH, orthostatic hypotension; SBP, systolic blood pressure; SH, supine hypertension. ΔS(D)BP = S(D)BP supine − S(D)BP standing. Values are number (%), mean (standard deviation), or median (interquartile range), as appropriate.