Table 5.
Linear regression analysis for blood pressure components in relation to CMBs count.
| Blood pressure component | Any CMBs |
Deep or infratentorial CMBs |
Lobar CMBs |
|||
|---|---|---|---|---|---|---|
| B (SE) | 95% CI | B (SE) | 95% CI | B (SE) | 95% CI | |
| Unadjusted | ||||||
| Supine SBP, per SD increase | 0.167 (0.082)a | 0.004 to 0.331 | 0.165 (0.080)a | 0.007 to 0.323 | 0.003 (0.024) | − 0.044 to 0.050 |
| ΔSBP, per SD increase | 0.074 (0.067) | − 0.058 to 0.207 | 0.082 (0.065) | − 0.047 to 0.210 | − 0.008 (0.019) | − 0.045 to 0.030 |
| ΔDBP, per SD increase | 0.088 (0.080) | − 0.070 to 0.247 | 0.089 (0.078) | − 0.065 to 0.243 | − 0.000 (0.023) | − 0.045 to 0.045 |
| Both OH and SH, present vs. absent | 0.383 (0.125)b | 0.136 to 0.632 | 0.384 (0.121)b | 0.145 to 0.623 | 0.000 (0.037) | − 0.073 to 0.073 |
| 24-hour SBP, per SD increase | 0.120 (0.082) | − 0.043 to 0.283 | 0.087 (0.080) | − 0.072 to 0.245 | 0.034 (0.023) | − 0.012 to 0.080 |
| Daytime SBP, per SD increase | 0.097 (0.087) | − 0.074 to 0.269 | 0.077 (0.084) | − 0.089 to 0.243 | 0.020 (0.025) | − 0.028 to 0.069 |
| Daytime DBP, per SD increase | 0.082 (0.085) | − 0.086 to 0.250 | 0.077 (0.082) | − 0.085 to 0.240 | 0.004 (0.024) | − 0.044 to 0.052 |
| Nighttime SBP, per SD increase | 0.023 (0.081) | − 0.137 to 0.183 | − 0.016 (0.078) | − 0.171 to 0.139 | 0.039 (0.023) | − 0.006 to 0.084 |
| Model 1 | ||||||
| Supine SBP, per SD increase | 0.094 (0.086) | − 0.076 to 0.263 | 0.095 (0.083) | − 0.071 to 0.260 | − 0.001 (0.025) | − 0.051 to 0.049 |
| ΔSBP, per SD increase | 0.029 (0.066) | − 0.102 to 0.160 | 0.041 (0.065) | − 0.087 to 0.169 | − 0.012 (0.019) | − 0.050 to 0.265 |
| ΔDBP, per SD increase | 0.120 (0.082) | − 0.043 to 0.283 | 0.109 (0.080) | − 0.050 to 0.268 | 0.011 (0.024) | − 0.037 to 0.059 |
| Both OH and SH, present vs. absent | 0.291 (0.127)a | 0.040 to 0.542 | 0.301 (0.123)a | 0.057 to 0.545 | − 0.010 (0.038) | − 0.085 to 0.038 |
| 24-hour SBP, per SD increase | 0.067 (0.081) | − 0.094 to 0.228 | 0.036 (0.080) | − 0.122 to 0.193 | 0.031 (0.024) | − 0.016 to 0.078 |
| Daytime SBP, per SD increase | 0.055 (0.085) | − 0.113 to 0.223 | 0.037 (0.083) | − 0.126 to 0.201 | 0.018 (0.025) | − 0.031 to 0.067 |
| Daytime DBP, per SD increase | 0.120 (0.082) | − 0.043 to 0.283 | 0.109 (0.080) | − 0.050 to 0.268 | 0.011 (0.024) | − 0.037 to 0.059 |
| Nighttime SBP, per SD increase | − 0.049 (0.081) | − 0.209 to 0.111 | − 0.086 (0.078) | − 0.241 to 0.070 | 0.036 (0.023) | − 0.010 to 0.083 |
| Model 2 | ||||||
| Supine SBP, per SD increase | 0.093 (0.072) | − 0.051 to 0.237 | 0.078 (0.070) | − 0.061 to 0.217 | 0.015 (0.024) | − 0.034 to 0.063 |
| ΔSBP, per SD increase | 0.039 (0.055) | − 0.071 to 0.148 | 0.050 (0.053) | − 0.056 to 0.155 | − 0.011 (0.018) | − 0.048 to 0.025 |
| ΔDBP, per SD increase | 0.055 (0.068) | − 0.080 to 0.190 | 0.063 (0.066) | − 0.066 to 0.193 | − 0.009 (0.023) | − 0.054 to 0.037 |
| Both OH and SH, present vs. absent | 0.253 (0.111)a | 0.036 to 0.472 | 0.249 (0.106)a | 0.038 to 0.459 | 0.004 (0.038) | − 0.071 to 0.079 |
| 24-hour SBP, per SD increase | 0.039 (0.069) | − 0.097 to 0.174 | 0.015 (0.066) | − 0.115 to 0.146 | 0.023 (0.023) | − 0.022 to 0.068 |
| Daytime SBP, per SD increase | 0.029 (0.071) | − 0.112 to 0.169 | 0.010 (0.068) | − 0.126 to 0.145 | 0.019 (0.024) | − 0.028 to 0.066 |
| Daytime DBP, per SD increase | 0.066 (0.070) | − 0.073 to 0.205 | 0.065 (0.068) | − 0.069 to 0.199 | 0.001 (0.0234) | − 0.045 to 0.048 |
| Nighttime SBP, per SD increase | − 0.068 (0.068) | − 0.201 to 0.066 | − 0.091 (0.065) | − 0.219 to 0.038 | 0.023 (0.023) | − 0.022 to 0.068 |
CMBs, cerebral microbleeds; DBP, diastolic blood pressure; OH, orthostatic hypotension; SBP, systolic blood pressure; SH, supine hypertension; SD, standard deviation; SE, standard error. ΔS(D)BP = S(D)BP supine − S(D)BP standing. Model 1: adjusted for age and sex; Model 2: additionally adjusted for hypertension, diabetes mellitus, history of stroke, antiplatelet treatment, and advanced white matter hyperintensities.
a
p < 0.05.
b
p < 0.01.