Table 2.

The role of water-soluble vitamins in multiple sclerosis.

Vitamins	Vitamin serum level in patients	Immune-related role	Neural- or myelin-related role	Clinical remarks	References
Vitamin C	High	No evidence	Effective in dendritic cell maturation	Not suggested	[102], [105], [106], [107], [108], [109]
Vitamin B9, B12	Low	Immune regulator	Effective in homocystein uptake effective in myelin synthesization	Improves EDSS reduces relapses	[110], [111], [112], [113], [114], [115], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127]
Vitamin B6	Controversial	No evidence	Effective in myelin synthesization	Reduces the risk of myelin damage	[129], [130]
Vitamin B3	Controversial	No evidence	Reduces inflammation	Improves EDSS	[135], [136], [137]
Vitamin B1	Controversial	No evidence	Increases T-cell proliferation	Reduces fatigue	[138], [139], [140]