Table 2. Univariate analysis of correlation between various clinical variables and use of second- and third-line chemotherapy.

Variables	Odd ratio (95% confidence interval)	P value
Age <70	2.14 (1.27–3.62)	0.004
Low Charlson comorbidity index	1.45 (1.19–1.77)	<0.001
WHO performance status 0	1.57 (0.94–2.60)	0.08
Female gender	1.09 (0.66–1.80)	0.73
Colon cancer	1.17 (0.71–1.94)	0.53
Stage IVB	1.65 (1.003–2.71)	0.049
No metastasectomy	1.63 (0.93–2.88)	0.09
Intact primary tumor	1.16 (0.69–1.94)	0.58
Distance to cancer center <100 km	1.61 (0.99–2.64)	0.057
Asymptomatic primary tumor	1.22 (0.74–2.01)	0.43
Normal albumin	1.01 (0.62–1.64)	0.96
Alkaline phosphatase <120	1.14 (0.86–2.29)	0.17
Bilirubin	1.35 (0.43–4.25)	0.60
BUN	0.73 (0.29–1.87)	0.51
CEA >5	1.32 (0.75–2.33)	0.32
Extrahepatic metastases	1.61 (0.99–2.62)	0.056
Hemoglobin >120 g/L	1.44 (0.88–2.36)	0.15
Radiation	1.36 (0.77-2.42)	0.29
Normal WBC	1.29 (0.68–2.44)	0.45

WHO, World Health Organization; BUN, blood urea nitrogen; CEA, carcinoembryonic antigen; WBC, white blood cell.