Table 3. Multivariate analysis of clinical variables and use of second- and third-line therapy after adjustment of other variables.

Variables	Odd ratio (95% confidence interval)	P value
No metastasectomy	1.89 (1.03–3.46)	0.03
Distance to cancer center <100 km	1.69 (1.003–2.84)	0.049
Low Charlson comorbid index	1.45 (1.19–1.77)	0.02
Age <70	1.06 (0.45–2.47)	0.89
WHO PS of 0	1.45 (0.85–2.47)	0.17
Stage IVB	1.50 (0.91–2.59)	0.10

WHO PS, World Health Organization performance status.