Table 3.
List of metabolites that varied before and 120 min after oral glucose tolerance
| Type of OGTT | Glc/OGTT | PHS/OGTT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject group (Q2) | GU−/NGT (0.354) | IGT (0.405) | GU−/NGT (0.098) | IGT (0.370) | ||||||||
| VIP | r | VIP | r | VIP | r | VIP | r | |||||
| Acethyl‐carnitine | ○ | 1.558 | −0.673 | ○ | 1.224 | −0.435 | ||||||
| Adenine | ○ | 1.061 | −0.518 | ○ | 1.299 | −0.651 | ○ | 1.545 | −0.518 | |||
| Allantoate | ○ | 1.061 | −0.600 | |||||||||
| Asparagine | ○ | 1.000 | −0.454 | |||||||||
| Betaine‐aldehyde | ○ | 1.147 | 0.460 | |||||||||
| Carbamoyl aspartate | ○ | 1.109 | −0.605 | ○ | 1.446 | −0.499 | ||||||
| Dimethyl‐arginine | ○ | 1.138 | −0.612 | |||||||||
| Dopamin | ○ | 1.363 | −0.737 | ○ | 1.259 | −0.669 | ||||||
| Ethanolamine | ○ | ○ | 1.110 | −0.507 | ||||||||
| Histidine | ○ | 1.170 | −0.584 | ○ | 1.105 | −0.509 | ||||||
| Luecine/Isoluecine | ○ | 1.338 | −0.697 | ○ | 1.211 | −0.593 | ○ | 1.369 | −0.450 | |||
| Methylcysteine | ○ | 1.191 | −0.584 | ○ | 1.299 | −0.651 | ||||||
| N‐acetyl‐glutamine | ○ | 1.285 | −0.435 | |||||||||
| Quinolinate | ○ | 1.077 | −0.596 | |||||||||
| Phenylpropiolic acid | ○ | 1.384 | 0.565 | |||||||||
| Pipecolic acid | ○ | 1.531 | 0.681 | |||||||||
| Taurine | ○ | 1.363 | −0.737 | |||||||||
| Uracil | ○ | 1.170 | −0.584 | ○ | 1.058 | −0.525 | ||||||
All molecules selected as “altered by oral glucose tolerance test (OGTT) by orthogonal projections to latent structures discriminant analysis” in any of four sets of comparison (marked by circles [○]) are shown. The values of variable importance in projection (VIP) and correlation coefficient are given for comparisons that met the selection criteria (VIP > 1.0, r > 0.4 or r < −0.4). The metabolites are shown in alphabetical order. GU−, glycosuria‐negative; NGT, normal glucose tolerance.