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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: Neuron. 2018 Apr 19;98(3):547–561.e10. doi: 10.1016/j.neuron.2018.03.043

Figure 8. CALHM3 is essential for GPCR-mediated taste perception.

Figure 8

(A-C) Wild-type and Calhm3–/– mice preference scores during 48-h two-bottle choice tests (A) and lick rates during 5-sec brief-access tests relative to licking when water was presented (B), and chorda tympani nerve responses to sweet, umami, bitter, sour, and salty taste stimuli (C). Symbols depict means ± s.e.m. (n = 6 – 19 mice per group; see METHODS); *P < 0.05 (post hoc LSD or Tukey-Kramer tests). Chorda tympani nerve responses to NaCl were examined in the presence of 100 μM amiloride to expose activation of ENaC-insensitive salt transduction at high concentrations. See also Figure S8 and Table S1.