Table 2.
Prevalence of IgE levels < LLOD in patients with CVID
| Study | Cohort; n | IgE < LLOD (2–4 IU/ml) | Low IgE (Cutoff used) |
|---|---|---|---|
| Stites, 1972 [9]a | Adults; n=12 | Not reported | 12 (<7 IU/ml) |
| Waldmann, 1972 [10]a | Adults and children; n=18 | 18 | 18 |
| McLaughlan, 1974 [11]a | Adults; n=22 | 3 | 21 (<20 IU/ml) |
| Iio, 1977a | Adult; n=36 | Not reported | 28 (<6 IU/ml) |
| Agondi et al, 2010 [14] | Adults; n=62 | 42 | 60 (<16 IU/ml) |
| Unsworth, 2011 [15] | Adults and children; n=19 | 17 | 19 (<20 IU/ml) |
| Agondi et al, 2013 [13] | Adults; n=72 | 62 | Not reported |
| Hartman et al, 2017 [16] | Adults; n=12 | 12 | 12 |
| Internal Cohort | Adults and children, n=181 | 134 | 169 (<10 IU/ml) |
| USIDNET | Adults and children; n=173 | 90 | 141 (<10 IU/ml) |
| Total | N=607 | 378 of 559 | 480 of 535 |
a
Not included in meta-analysis since total IgE measured prior to introduction of ImmunoCAP assay