Table 2.

Sensitivity and specificity at different thresholds in controls (normal test controls and disease test controls) and patients showing the optimal threshold at 0.9

Classifier threshold	Two test groups		FCD detected (Total=61)	Sensitivity	Specificity	Youden index
	Healthy test group detected (Total=35)	Disease test group detected(Total=15)
0.1	35	15	49	80.3%	0	−19.7%
0.2	35	15	49	80.3%	0	−19.7%
0.3	34	14	49	80.3%	4.0%	−15.7%
0.4	32	144	49	80.3%	8.0%	−11.7%
0.5	29	12	49	80.3%	18.0%	−1.7%
0.6	20	11	48	78.7%	38.0%	16.7%
0.7	14	9	48	78.7%	54.0%	32.7%
0.8	9	5	46	75.4%	72.0%	47.4%
0.9	3	2	45	73.7%	90.0%	63.7%
0.95	2	2	42	68.9%	92.0%	60.8%
0.96	2	2	42	68.9%	92.0%	60.8%
0.97	2	1	41	67.2%	94.0%	61.2%
0.98	2	1	38	62.3%	94.0%	56.3%