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. Author manuscript; available in PMC: 2018 Aug 19.
Published in final edited form as: Oncogene. 2018 Feb 19;37(18):2469–2480. doi: 10.1038/s41388-017-0076-0

Figure 2. BMA097 inhibition of STAT3 activity and expression of STAT3 target genes.

Figure 2

(A and B) Dose response and time course of BMA097 inhibition of STAT3-dependent luciferase expression. MDA-MB-231 cells with stable expression of STAT3-dependent luciferase were incubated with BMA097 at different concentrations (A) or at 2 μM for different times (B) followed by determination of luciferase activity. (C) BMA097 inhibition of STAT3 downstream target gene expression. MDA-MB-231 cells were treated without or with different concentrations of BMA097 followed by real-time RT-PCR analysis of mRNAs encoding STAT3, cyclin D1 and Bcl-xL. GAPDH was used as an internal control. (n=3; *p<0.05; **p<0.01).