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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Nov 4;81:78–87. doi: 10.1016/j.semcdb.2017.09.026

Figure 2. Nrdp1 promotes the Vangl-dependent poly-ubiquitination of Dvl.

Figure 2

Nrdp1 negatively regulates Wnt/PCP signaling by promoting the Vangl-dependent K63-linked polyubiquitination of Dvl. Polyubiquitination inhibits Wnt/Fzd-mediated Dvl recruitment to the plasma membrane and concomitant activation, resulting in the suppression of downstream Wnt/PCP signaling.