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. 2018 May 3;8:6952. doi: 10.1038/s41598-018-25088-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects during the acute and subacute stages of HI insult. (A) – insulted pups curved to the left (#3 and 4), while the sham pups did not (#6). (B) – cytotoxic oedema development in the ipsilateral hemisphere (dotted line) and contralateral hemisphere (bold line) was detected immediately after HI insult at the striatal level (pup #16). (C) – 3D image of the brain depicting the extent of the lesion (in red) in the ipsilateral hemisphere (pup #7); D-V and A-P black arrows indicate the dorso-ventral and anterior-posterior directions, respectively. (D) – subacute stage: areas of simultaneously occurring vasogenic and cytotoxic oedema are shown in green and red, respectively (pup #9).