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. 2018 May 3;8:6952. doi: 10.1038/s41598-018-25088-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological and MSI assessment of the HI-insulted neonatal rat brains during the acute stage of HIE. Panel A: Haematoxylin-eosin stained section demonstrating the early cellular response; a – expanded region of the ipsilateral hemisphere (indicated by the black rectangle shown in (A)) depicting the cytotoxic oedema-afflicted neurons with signs of swelling and vacuolization (red circles). MALDI MS images showing the altered distribution of PC (16:0/16:0) in the sodiated (panel B, m/z 756.550) and potassiated (panel D, m/z 772.525; signal was overscaled to 120% to provide better contrast) form. Quantitative LA-ICP-MS images of the elemental sodium (panel C) and potassium (panel E) distribution (for details see Supplementary Figure S4). MCtx (motor cortex), cc (corpus callosum), SCtx (somatosensory cortex), ec (external capsule), Cpu (caudate putamen = striatum). Different image scaling (B/D versus C/E) are due to different FlexImaging (Bruker Daltonics, Bremen, Germany) and ImageLab⁴² programs.