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. 2018 May 3;8:6954. doi: 10.1038/s41598-018-25295-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased autophagy gene expression in kidneys of db/db mice relative to control db/+ mice.qRT-PCR analysis of autophagy genes in (A) kidney cortex lysates (n = 4 per group) and (B) glomerular lysates, from 10–12 week old - db/db mice and db/+ mice (n = 3 per group). (C) Representative immunostaining and (D) quantification for p62, Atg5 and glomerular area from cortical sections of db/+ and db/db mice; (n = 3 per group). Scale bar, 20 µm. x400 (10 × 40) magnification. (E) Western blot and (F) quantification of LC3 levels (LC3-2/Tubulin) from renal glomerular lysates of 10–12-week-old db/+ and db/db mice; (n = 4 per group). Uncropped scans are presented in Supplementary Fig. 1. *P < 0.05; **P < 0.01; ***P < 0.001.