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. 2018 May 3;8:6954. doi: 10.1038/s41598-018-25295-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased expression of autophagy genes in kidneys of STZ-injected diabetic mice relative to control mice and reversal of this effect on some genes with LNA-anti-miR-192 oligonucleotides.qRT-PCR analysis of autophagy genes in kidney cortex lysates from control (n = 3) and STZ-injected mice. (A) 2 weeks and (B) 16 weeks after induction of diabetes treated with either negative control (NC) (n = 3) or LNA-anti-miR-192 (LNA) oligonucleotides (n = 4). Scale bar, 20 µm. x400 (10 × 40) magnification. (C) Representative immunostaining and quantification for Atg5 or p62 and glomerular area from cortical sections of control mice treated with NC oligonucleotides (Control-NC) (n = 3), STZ-injected diabetic mice treated with NC oligonucleotides (STZ-NC) (n = 3), and STZ-injected diabetic mice treated with LNA-anti-miR-192 oligonucleotides (STZ-LNA) (n = 4). (D) Western blot and quantification of LC3 levels (LC3-2/LC3-1) from kidney cortex lysates of Control-NC mice (n = 3), STZ-NC mice (n = 3), and STZ-LNA mice (n = 4) 16 weeks post diabetes induction. Uncropped scans are presented in Supplementary Fig. 1. *P < 0.05; **P < 0.01; ***P < 0.001.