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. 2018 Apr 27;9:908. doi: 10.3389/fimmu.2018.00908

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Copyright © 2018 Zhang, Björkman, Cai, Liu, Wang, Li, Xia, Sun, Kristiansen, Wang, Han, Hammarström and Pan-Hammarström.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of diet pattern on the diversity of immune system. Diversities of B-cell receptor (A) and T-cell receptor (B) were analyzed in all study subjects from the different groups. Representative tree map from samples collected at days 0 and 91 from one individual in the study group are shown on top. Each dot represents one unique complementary determining regions 3 (CDR3)-V-J combination, whereas the size illustrates the number of sequences of each CDR3-V-J combination. Changes in D50 values and diversity (unique/total CDR3s) between days 0 and 91 in each group are shown in the middle and at the bottom panels, respectively. Each line represents one individual. Statistical calculations were performed by Wilcoxon signed-rank test. *p < 0.05.