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. 2018 Apr 27;9:920. doi: 10.3389/fimmu.2018.00920

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Copyright © 2018 Lee, Ko, Song and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lysophosphatidylcholine (LPC) controls Mycobacterium tuberculosis (Mtb) growth and inflammatory cytokine production. Bone marrow-derived macrophages (BMDMs) isolated from wild-type (WT) and G2A knockout (KO) mice were infected with avirulent Mtb H37Ra (A) or virulent Mtb H37Rv (B) [at multiplicity of infections (MOIs) of 0.1 and 1] and stimulated with different doses of LPC for 24 h. (A,B) Intracellular bacteria were assayed for viability based on the number of colony-forming units (CFUs) after 3 weeks. (C,D) Production of TNF-α and IL-6 (C) and IL-10 (D) was measured by enzyme-linked immunosorbent assay in the culture supernatant of WT or G2A KO BMDMs at 24 h. The experiments were performed in triplicate. Data obtained from independent experiments (mean ± SD) were analyzed using one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons; *p < 0.05; **p < 0.01; ***p < 0.001, and not significant (ns) (p > 0.05).