Table 1.
Hematological characteristics of 202 consecutive patients with chronic hemolytic anemias divided according to disease.
| SPLENECTOMY | Hb (gr/dL) | Reticulocyte (x109/L) | MCV (fL) | MCH (pg/cell) | MCHC (gr/dL) | RDW (%) | Uncojugated bilirubin (mg/dL) | RBC morphology** (%) | EMA (% reduction) | |
|---|---|---|---|---|---|---|---|---|---|---|
| (F 12–16; M 13.5–17.5) | (24–84) | (78–99) | (25–35) | (31–37) | (11.8–14.8) | (<0.8) | Na | (<11%) | ||
| HS | NO | 12 | 266 | 84 | 29.7 | 35.9 | 18.4 | 1.95 | 9 | −29 |
| (N = 92) | (6.3/16.4) | (35/649) | (69/95.4) | (23.5/34.7) | (30.1/40.1) | (11.4/26.3) | (0.5/10.1) | (2/59) | (−62/+2) | |
| YES | 15.7 | 145 | 86.6 | 32.3 | 35.7 | 13 | 0.71 | 7.5 | −29 | |
| (N = 16) | (9.3/17.6) | (51/362) | (75/97.3) | (30.4/33.1) | (29.4/38) | (11.1/19.7) | (0.2/9.3) | (1/19) | (−38/−16) | |
| HE | NO | 13.8 | 59 | 84 | 29.5 | 35 | 13.4 | 0.9 | 43 | −8 |
| (N = 15) | (9.8/15.9) | (31/260) | (56.3*/92.2) | (19.3/32) | (33.1/36.4) | (11.8/17.5) | (0.4/1.4) | (10/90) | (−14/+4) | |
| YES | Na | Na | Na | Na | Na | Na | Na | Na | Na | |
| (N = 0) | ||||||||||
| HSt | NO | 9.9 | 260 | 102 | 36.7 | 35.7 | 16 | 3.2 | 8 | +6 |
| (N = 5) | (8.3/13) | (104–273) | (71.9*/110) | (24.8/39.2) | (34.5/37.8) | (13.9/18.6) | (1.7/4.8) | (6/22) | (−5/+15) | |
| YES | 11.7 | 272.5 | 105 | 37.5 | 35 | 16 | 1.7 | 13 | +22 | |
| (N = 4) | (11/13.2) | (166/654) | (101/109) | (34.1/40.1) | (33.5/38.3) | (15.1/19.7) | (0.8/6.7) | (6/33) | (+5/+30) | |
| PK, P5′N, | NO | 10.3 | 171 | 94 | 32.8 | 34.3 | 13.6 | 2.2 | Na | +7 |
| (N = 26) | (5/14.5) | (53/727) | (67.6*/108) | (23.1/36.7) | (28.8/36.3) | (10.9/21.4) | (0.5/9.6) | (−9/+22) | ||
| TPI, GPI | YES | 9.3 | 508 | 120 | 37.8 | 32.6 | 15.3 | 5.2 | Na | +23 |
| (N = 11) | (7.5/12) | (88/1740) | (85.3/127) | (27.8/41.1) | (31.6/33.5) | (12.7/24.7) | (1.3/13.5) | (+19/+33) | ||
| CDAII | NO | 10.7 | 92.5 | 86.4 | 30 | 35 | 19.4 | 2.2 | Na | −13 |
| (N = 9) | (7.4/12.7) | (64/121) | (75.2/94) | (25.3/31.6) | (32.9/38.2) | (13.4/24) | (1/3.8) | (−19/+17) | ||
| YES | 10.1 | 40 | 94 | 33.6 | 33.7 | 20 | 1.7 | Na | −20.5 | |
| (N = 7) | (8.3/11.3) | (35/63) | (83.4/96.7) | (27.4/33.7) | (31.2/34.9) | (17.1/29.7) | (0.7/5.7) | (−28/−11) | ||
| PNH | NO | 10.6 | 97 | 93.7 | 32 | 32.6 | 15.7 | 0.9 | Na | +3 |
| (N = 9) | (7.9/13.6) | (52/248) | (81.3/111) | (27.7/34.4) | (31.1/34.9) | (12.8/20) | (0.5/1.4) | (+1/+16) | ||
| YES | Na | Na | Na | Na | Na | Na | Na | Na | Na | |
| (N = 0) | ||||||||||
Values are expressed as median (range); Hb, hemoglobin, MCV, mean cell volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width; RBC, red blood cell; EMA, EMAbinding test; Na, not available.
*
beta-trait.
**
% spherocytes for HS; % elliptocytes for HE; % stomatocytes for HSt.