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. 2018 Apr 27;9:903. doi: 10.3389/fimmu.2018.00903

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Copyright © 2018 Lowe, Demaret, Bangani, Nakiwala, Goliath, Wilkinson, Wilkinson and Martineau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of cell depletions on supernatant cytokines and chemokines from Mycobacterium tuberculosis-infected blood. (A–R). Supernatants from the experiments presented in Figure 1 (blood from 20 donors depleted of CD4+, CD8+, CD14+, CD15+ or no cells and infected with M. tuberculosis-lux for 96 h) were aspirated and stored at −80°C until analysis by Luminex™ technology. Box and whisker plots represent median, interquartile range, minimum and maximum values for each analyte. Abbreviations: VEGF, vascular endothelial growth factor; TNF, tumor necrosis factor; IFN, interferon; IL, interleukin; IL-2R, interleukin-2 receptor; IL-1RA, interleukin-1 receptor antagonist; FGFb, fibroblast growth factor basic; EGF, epidermal growth factor; CXCL, C-X-C motif ligand; CCL, C-C chemokine ligand; CD, cluster of differentiation.

Impact of cell depletions on supernatant cytokines and chemokines from Mycobacterium tuberculosis-infected blood. (A–R). Supernatants from the experiments presented in Figure 1 (blood from 20 donors depleted of CD4+, CD8+, CD14+, CD15+ or no cells and infected with M. tuberculosis-lux for 96 h) were aspirated and stored at −80°C until analysis by Luminex™ technology. Box and whisker plots represent median, interquartile range, minimum and maximum values for each analyte. Abbreviations: VEGF, vascular endothelial growth factor; TNF, tumor necrosis factor; IFN, interferon; IL, interleukin; IL-2R, interleukin-2 receptor; IL-1RA, interleukin-1 receptor antagonist; FGFb, fibroblast growth factor basic; EGF, epidermal growth factor; CXCL, C-X-C motif ligand; CCL, C-C chemokine ligand; CD, cluster of differentiation.