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. 2018 Apr 27;9:903. doi: 10.3389/fimmu.2018.00903

Figure 4.

Figure 4

Detailed impact of viable and necrotic neutrophil augmentation on supernatant cytokines and chemokines from Mycobacterium tuberculosis-infected blood. (A–O) Cytokines and chemokines were measured in 96-h supernatants of M. tuberculosis-infected blood which had been augmented with necrotic autologous neutrophils (“+Necrotic”), with medium only (“+Nil”), or with viable autologous neutrophils (“+Viable”). Bars represent mean ± SD for each analyte found to be significant in principal component analysis. Presented are p-values from one-way ANOVA with Bonferroni correction comparing both augmented conditions with the medium-only control: *p < 0.05, **p < 0.01, ***p < 0.001. Data are from nine separate donors in four independent experiments. Abbreviations: IL, interleukin; TNF, tumor necrosis factor; FGFb, fibroblast growth factor basic; G-CSF, granulocyte-colony stimulating factor; GM-CSF, granulocyte macrophage-colony stimulating factor; CCL, C-C chemokine ligand; CXCL, C-X-C motif ligand; IL-2R, interleukin-2 receptor; HGF, hepatocyte growth factor.