Figure 3.

Inflammasomes in breast cancer. IL-1β promotes the proliferation, migration, invasion of breast cancer through the secretion of chemokines: VEGF and HGF. Mesenchymal stem cells (MSCs) that are stimulated by IL-1β also produce chemokines: IL-1β. Adipokines promote breast cancer cell migration and invasion by stimulating the expression and secretion of IL-18 in tumor-associated macrophages (TAMs). However, IL-18 overexpressing MSCs generated from human umbilical cord (hUMSCs) suppress the proliferation, migration and invasion of breast cancer cells. AIM2 and ASC also inhibit breast cancer development through promoting apoptosis.