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. 2018 Apr 1;8(4):662–674.

Figure 5.

Figure 5

Alteration of JAK2 expression affected the influence of miR-337-3p on HCC cells. A. Western blotting assays were performed to detect JAK2 and p-STAT3 expression levels in miR-337-3p-overexpressing SMMC7721 cells with or without JAK2 upregulation. B. CCK-8 assays were used to evaluate the effect of JAK2 upregulation on cell proliferation in miR-337-3p overexpressed SMMC7721 cells. Upregulation of JAK2 restored the suppressed growth in miR-337-3p overexpressed SMMC7721 cells (P < 0.01). C. Colony formation assays showed that JAK2 upregulation reversed the inhibitory effect of miR-337-3p overexpression in SMMC7721 cells (P < 0.01). D. Transwell assays were performed to examine the effect of JAK2 upregulation on cell migration and invasion in miR-337-3p-overexpressed SMMC7721 cells (P < 0.01). Data are shown as mean ± SD. *P < 0.05, **P < 0.01.