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. 2018 Apr 1;8(4):748–760.

Figure 2.

Figure 2

MALAT1 and foxq1 are direct targets of miR-124. Real-time PCR analysis of MALAT1, miR-124, and foxq1 mRNA expression in T24 cells (A) and BIU-87 cells (B) transfacted with Control, miR-124 mimics, respectively. Real-time PCR analysis of MALAT1, miR-124, and foxq1 mRNA expression in T24 cells (C) and BIU-87 cells (D) transfacted with Scramble, si-miR-124, respectively. (E) The putative miR-124-binding site in 3’UTR region of MALAT1. The relative luciferase activity was suppressed in cells transfected with the reporter vector MALAT1-WT, not in cells transfected with MALAT1-MUT. (F) The putative miR-124-binding site in 3’UTR region of foxq1. The relative luciferase activity was down-regulated in cells transfected with the reporter vector foxq1-WT, not in cells transfected with foxq1-MUT. Data are shown as mean ± SEM, *P < 0.05, ***P < 0.001.