Figure 5.

MALAT1 promotes tumor growth and metastasis in vivo. MALAT1/T24 or Control/T24 cells were subcutaneously implanted into nude mice (n=12/group). A. Tumor volume was calculated every one week. 6 weeks later, tumors were removed and tumor weight was measured. B. Livers and lungs were dissected for histology analysis to evaluate distant metastasis. C. Real-time PCR analysis of miR-124 expression and western blot analysis of foxq1, E-cadherin, and Vimentin expression in tissues of resected tumors. Data are presented as mean ± SEM. *P < 0.05.