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JAK1 is a direct target of miR-214 in lung cancer. A. The human JAK1 3’UTR binding site for miR-214. B. miR-214 targeted the wild-type but not the mutant 3’UTR of JAK1. C. Ectopic expression of miR-214 down-regulated JAK1 mRNA expression in A549 and H522 cells as determined by qRT-PCR. D. miR-214 decreased JAK1 protein level in A549 and H522 by western blot. Each bar represents the mean ± SD. *P < 0.05, student t-test.
