Figure 1.

Quercetin enrich diet (1 month-13 month) prevented cognitive dysfunction and decreased amyloid plaques and astrogliosis. Schematic for administration of normal or quercetin enrich (2 mg/g) diet and all of experimental examination (A). Spatial learning and memory functions were improved at 13 month in quercetin enrich diet (1 mo-13 mo) mice compared with normal diet mice identified by Morris water maze (B-E). Immunostaining was performed to identify GFAP, 6E10 and DAPI in cortex and hippocampus of quercetin enrich diet (1 month-13 month) mice and normal diet mice (F and I). The number and area of amyloid plaques and GFAP+ cells were decreased in cortex and hippocampus of quercetin enrich diet (1 month-13 month) mice compared with normal diet mice (G and J). The expression of CTFβ and GFAP were decreased but the expression of APP was not changed in cortex and hippocampus of quercetin enrich diet (1 month-13 month) mice compared with normal diet mice (H and K). All data are presented as means ± standard error of the mean, n = 12, *P < 0.05, **P < 0.01, ***P < 0.001 compared with normal diet mice, mo represented as months.