Figure 3.

Thermodynamic fluctuations and the nature of the collapse transition. (A) Apparent heat capacities as a function of concentration (circles) together with the linear fit (lines) from which absolute heat capacities are extracted. (B) The absolute heat capacity (blue circles) together with the folded Freire (continuous black) and unfolded Makhatadze-Privalov (MP; dashed black) baselines. Red curve is a fit to the experimental data derived from the variable barrier model. The dark green curve (right ordinate) represents the temperature dependent excess enthalpic fluctuations of the system in units of (kJ mol⁻¹)². (C) Probability distribution of microstates as a function of enthalpy as the order parameter. Note that the densities are unimodal at all temperatures.