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. 2018 Feb 2;46(8):e50. doi: 10.1093/nar/gky065

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Relationships between Hi-C interaction frequencies and reconstructed spatial distances derived from the chromatin structures modeled by GEM on experimental Hi-C data. (A–D) The latent functions inferred by GEM between Hi-C interaction frequencies and reconstructed spatial distances on human chromosome 13 at 1Mb resolution, human chromosome 14 at 1Mb resolution, a 130Mb-180Mb region of human chromosome 1 at 250 kb resolution, and yeast chromosome 6 at 10 kb resolution, respectively. The functions were obtained by curve fitting to the points representing the pairs of Hi-C interaction frequencies and reconstructed spatial distances in the modeled structures. The expressions of the derived functions and the fitting results measured in terms of the root-mean-square errors (RMSEs) are also shown.