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. 2018 Mar 23;46(8):4129–4137. doi: 10.1093/nar/gky200

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — FRET histograms for GC and TG repeats at the indicated protein (hZα_ADAR1) concentrations. (A) FE histograms of a scrambled sequence in the absence (bottom) and presence (top) of 50 μM hZα_ADAR1. (B) FE histograms of (GC)₁₁ with various concentrations of hZα_ADAR1 (0, 0.1, 0.3, 0.4, 0.5 and 1 μM from bottom to top). A new peak at FE ∼0.15 corresponds to the Z-DNA state. (C) FE histograms of (TG)₁₁ with various concentrations of hZα_ADAR1 (0, 0.1, 0.5, 1, 5, 10, 15 and 50 μM from bottom to top). At 50 μM hZα_ADAR1, the peak at FE ∼0.2 becomes dominant. The curves (blue: Z-DNA, red: B*-DNA, black: B-DNA, green: donor-only) in each panel represent multiple Gaussian fits for histogram. Two vertical dotted lines in each panel are at FE = 0 (left) and 0.5 (right), which represent donor-only and B-DNA peaks, respectively.