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. 2018 Feb 13;46(8):4228–4240. doi: 10.1093/nar/gky090

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Human La displays length dependent affinity for poly(A). (A) Binding of recombinant human La for U10, U20, A10 and A20 was tested by electromobility shift assay (EMSA) using HepC hairpin RNA as competitor; gels for C10, C20, G10 and G20 provided in Supplementary Figure S1. (B) Graphical representation of EMSA results. (C) EMSA of human La for U10 and A20 in the presence of C10 as competitor. (D) Graphical representation of binding curves comparing La affinity for U10 and A20 with C10 versus HepC hairpin competitors.