Table 1.
MCP230 | ||
---|---|---|
Cytokines | 12 h | 1 d |
IL1β | 1.446 ± 0.1729 | 1.691 ± 0.2082a |
IL6 | 45.71 ± 8.457a | 10.61 ± 3.177a |
IL21 | 0.7346 ± 0.0256 | 1.034 ± 0.1367 |
IL17A | 0.6526 ± 0.1302 | 6.096 ± 1.666a |
IL22 | 0.9377 ± 0.0325 | 1.504 ± 0.158a |
IL17E | 0.7034 ± 0.0941 | 0.9023 ± 0.0322 |
KC | 5.629 ± 1.54 p = 0.053 | 2.591 ± 0.4729a |
MCP-1 | 6.337 ± 1.325a | 6.825 ± 0.2238a |
IL33 | 2.226 ± 0.1384a | 2.716 ± 0.1907a |
IL31 | 0.3472 ± 0.07782a | 0.4988 ± 0.0489 |
Levels of Th17 cytokines were determined in the lung homogenates of WT mice exposed to MCP230 at 12 h and 1 day post-exposure. Concentrations (pg/mg of lung protein) of all cytokines were measured using multiplex assay. Data are expressed as means ± SEM of fold change over Vehicle treated controls from 4 to 5 mice. ap < 0.05 compared to vehicle control, unpaired t test