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. 2018 May 3;18:524. doi: 10.1186/s12885-018-4440-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Next-generation sequencing based characterization of NCH644 and NCH421k CIN knockdown cells. a After CIN knockdown there are 409 upregulated and 258 downregulated genes in NCH644 CIN shRNA cells as compared to CTRL cells. b After CIN knockdown there are 172 upregulated and 66 downregulated genes in NCH421k CIN shRNA cells as compared to CTRL cells. c Heatmap of the Top100 differentially regulated genes (sorted by adjusted p-value, based on rlog normalized counts) in NCH644. Hierarchical clustering separates control cells and knockdown cells efficiently. d Heatmap of the Top100 differentially regulated genes (sorted by adjusted p-value, based on rlog normalized counts) in NCH421k. Hierarchical clustering separates control cells and knockdown cells efficiently