Table 4.
Associations of the 11 SNPs with FPG in 2030 Chinese children
| SNP | Nearest gene | Unadjusted for age- and sex-specific WHR-Z scores | Adjusted for age- and sex-specific WHR-Z scores | ||
|---|---|---|---|---|---|
| β (S.E.) | P-value | β (S.E.) | P-value | ||
| rs984222 | TBX15-WARS2 | −0.033 (0.016) | 0.043* | − 0.032 (0.016) | 0.045* |
| rs1011731 | DNM3-PIGC | 0.035 (0.024) | 0.137 | 0.031 (0.024) | 0.192 |
| rs4846567 | LYPLAL1 | −0.015 (0.017) | 0.390 | −0.013 (0.017) | 0.455 |
| rs10195252 | GRB14 | 0.010 (0.026) | 0.704 | 0.011 (0.025) | 0.671 |
| rs6795735 | ADAMTS9 | 0.033 (0.018) | 0.078 | 0.032 (0.018) | 0.083 |
| rs1294421 | LY86 | 0.010 (0.019) | 0.597 | 0.011 (0.019) | 0.565 |
| rs6905288 | VEGFA | −0.011 (0.018) | 0.553 | −0.011 (0.018) | 0.545 |
| rs9491696 | RSPO3 | 0.020 (0.016) | 0.196 | 0.021 (0.016) | 0.174 |
| rs1055144 | NFE2L3 | 0.018 (0.016) | 0.253 | 0.021 (0.016) | 0.181 |
| rs1443512 | HOXC13 | 0.013 (0.020) | 0.524 | 0.012 (0.020) | 0.543 |
| rs4823006 | ZNRF3-KREMEN1 | −0.007 (0.016) | 0.677 | −0.005 (0.016) | 0.751 |
| Unweighted GRS | – | 0.004 (0.006) | 0.464 | 0.005 (0.006) | 0.391 |
| Weighted GRS | – | 0.004 (0.006) | 0.502 | 0.004 (0.006) | 0.418 |
Linear regression was performed to examine the independent and cumulative effects of each SNP on FPG under an additive model adjusted for study group, sex, age and age squared, without or with adjustment for age- and sex-specific WHR-Z scores
FPG fasting plasma glucose, GRSgenetic risk score, SNP single nucleotide polymorphism, S.E standard error, WHR waist-hip ratio
*Two-sided P < 0.05