Table 10.
Assessment of ability to detect change of NVSA© scores with the sPGA and effect size
| Number of days of vomiting or Nausea | Number of vomiting episodes | Mean severity of Nausea | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| sPGA Week | sPGA | N | Difference in means | Effect Size | N | Difference in means | Effect size | N | Difference in means | Effect size |
| (Week 2 – Week 1) | No Change | 41 | 0.19 (0.98) | 0.08 | 42 | 0.51 (2.49) | 0.29 | 41 | 0.21 (0.93) | 0.17 |
| (Week 3 – Week 2) | No Change | 44 | −0.10 (0.97) | 0.04 | 47 | −0.01 (1.43) | 0.00 | 44 | −0.05 (0.74) | 0.04 |
| (Week 4 – Week 3) | No Change | 52 | 0.15 (1.10) | 0.06 | 52 | −0.01 (0.50) | 0.01 | |||
| (Week 5 – Week 4) | No Change | 47 | −0.00 (0.95) | 0.00 | 49 | −0.13 (1.18) | 0.06 | 47 | −0.04 (0.35) | 0.04 |
| (Week 6 – Week 5) | No Change | 45 | 0.07 (1.13) | 0.03 | 53 | 0.26 (1.24) | 0.17 | 45 | 0.03 (0.40) | 0.03 |
| (Week 7 – Week 6) | No Change | 44 | −0.01 (0.77) | 0.00 | 47 | −0.15 (0.75) | 0.07 | 44 | −0.04 (0.30) | 0.03 |
| (Week 8 – Week 7) | No Change | 47 | −0.13 (1.09) | 0.05 | 49 | −0.14 (0.77) | 0.08 | 47 | −0.12 (0.38) | 0.12 |
| (Week 2 – Week 1) | Any Improvement | 7 | −1.80 (2.43) | 0.73 | 7 | −1.02 (1.24) | 0.82 | |||
| (Week 3 – Week 2) | Any Improvement | 9 | −0.47 (2.37) | 0.20 | 8 | −3.77 (8.21) | 0.97 | 9 | −0.74 (1.11) | 0.53 |
| (Week 4 – Week 3) | Any Improvement | 7 | −1.06 (1.16) | 0.45 | 7 | −0.21 (0.39) | 0.22 | |||
| (Week 5 – Week 4) | Any Improvement | 7 | −1.26 (2.56) | 0.54 | 6 | −1.67 (2.73) | 0.79 | 7 | −0.26 (1.65) | 0.25 |
| (Week 6 – Week 5) | Any Improvement | 7 | 0.17 (2.52) | 0.07 | 7 | −0.26 (0.69) | 0.23 | |||
| (Week 7 – Week 6) | Any Improvement | 10 | −0.67 (1.56) | 0.27 | 8 | −2.06 (2.76) | 0.97 | 10 | −0.62 (1.46) | 0.49 |
| (Week 8 – Week 7) | Any Improvement | 7 | −1.05 (1.30) | 0.42 | 7 | −1.07 (6.47) | 0.60 | 7 | −0.29 (0.48) | 0.29 |
| (Week 2 – Week 1) | Any Worsening | 10 | 0.55 (1.99) | 0.22 | 11 | 2.40 (7.44) | 1.37 | 10 | 0.54 (1.05) | 0.44 |
| (Week 3 – Week 2) | Any Worsening | 9 | 0.56 (1.99) | 0.24 | 7 | −0.99 (4.63) | 0.26 | 9 | − 0.22 (1.85) | 0.16 |
| (Week 4 – Week 3) | Any Worsening | |||||||||
| (Week 5 – Week 4) | Any Worsening | 6 | 1.83 (1.72) | 0.78 | 6 | 0.76 (0.78) | 0.73 | |||
| (Week 6 – Week 5) | Any Worsening | 11 | 0.70 (1.56 | 0.28 | 6 | 1.42 (2.25) | 0.95 | 11 | 0.40 (0.56) | 0.36 |
| (Week 7 – Week 6) | Any Worsening | 8 | 0.33 (1.55) | 0.13 | 7 | 2.00 (2.58) | 0.94 | 8 | 0.51 (0.72) | 0.41 |
| (Week 8 – Week 7) | Any Worsening | 6 | −0.05 (0.88) | 0.02 | 6 | −0.06 (1.13) | 0.06 | |||
Empty rows = sample size < n = 6 and analyses not conducted. The within-patient effect size was defined as the within-patient change score (post-pre score) divided by pre (group) standard deviation