Figure 3.

The trend of numbers of days with pain during the study among the intervention and control group. Group A, placebo group; Group B, intervention group. C = Constipation-dominant, D = Diarrhea-dominant, M = Mixed. Time 1: Assessed at baseline (day 0); Time 2: The 4^th week (day 28) of treatment, 1^st on-drug period; Time 3: The 8^th week (day 56) of treatment, off-drug period; Time 4: The 12^th week (day 84) of treatment, 2^nd on-drug period