Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The trend of changes of the impact on daily life during the study among the intervention and control group. Group A, placebo group; Group B, intervention group. C = Constipation-dominant, D = Diarrhea-dominant, M = Mixed. Time 1: Assessed at baseline (day 0); Time 2: The 4th week (day 28) of treatment, 1st on-drug period; Time 3: The 8th week (day 56) of treatment, off-drug period; Time 4: The 12th week (day 84) of treatment, 2nd on-drug period
