Table I.

Genetic variants identified in GWAS of AD – allele frequencies by race. ARIC Study (1990 – 1992)

GWAS SNP dbSNP ID	Major/Minor Allele	Risk Allele	Chrom	Nearest Gene	AA MAF	White MAF	p*	Ref.
rs4147929	G/A	A	19	ABCA7	4.7	16.6	<0.001	[Lambert et al. 2013]
rs744373	A/G	G	2	BIN1	46.8	29.9	<0.001	[Seshadri et al. 2010]
rs7274581	T/C	T	20	CASS4	21.7	NA		[Lambert et al. 2013]
rs9349407	G/C	C	6	CD2AP	19.4	25.7	<0.001	[Naj et al. 2011]
rs3865444	C/A	C	19	CD33	7.4	32.6	<0.001	[Naj et al. 2011]
rs6485758	G/A	NA	11	CELF1	5.6	29.8	<0.001	[Lambert et al. 2013]
rs9331896	T/C	T	8	CLU	55.2	37.0	<0.001	[Lambert et al. 2013]
rs6656401	G/A	A	1	CR1	6.6	18.6	<0.001	[Lambert et al. 2009]
rs11767557	T/C	T	7	EPHA1	13.6	17.8	<0.001	[Naj et al. 2011]
rs17125944	T/C	C	14	FERMT2	5.1	9.1	<0.001	[Lambert et al. 2013]
rs9271174	G/C	NA	6	HLA-DRB1	21.7	27.1	<0.001	[Lambert et al. 2013]
rs35349669	C/T	T	2	INPP5D	15.2	49.0	<0.001	[Lambert et al. 2013]
rs190982	A/G	A	5	MEF2C	8.9	37.6	<0.001	[Lambert et al. 2013]
rs670139	G/T	T	11	MS4A4E	41.6	41.6	0.787	[Hollingworth et al. 2011]
rs12155159	A/G	NA	7	NME8	57.5	34.5	<0.001	[Lambert et al. 2013]
rs561655	A/G	A	11	PICALM	16.3	34.0	<0.001	[Naj et al. 2011]
rs17057043	G/A	NA	8	PTK2B	46.3	36.0	<0.001	[Lambert et al. 2013]
rs10498633	G/T	G	14	SLC24A4	12.8	22.6	<0.001	[Lambert et al. 2013]
rs11218343	T/C	T	11	SORL1	7.5	2.1	<0.001	[Lambert et al. 2013]
rs1476679	T/C	T	7	ZCWPW1	5.6	30.2	<0.001	[Lambert et al. 2013]

GWAS, genome-wide association study; AD, Alzheimer’s disease, dbSNP, The National Center for Biotechnology’s Information SNP database; SNP, single nucleotide polymorphism; ID, identification; Risk allele, allele associated with AD risk in genome-wide association study; Chrom., chromosome; AA, African-American; MAF, minor allele frequency; p*, p-value for comparison of genotype frequencies between races; Ref.; reference; rs, reference SNP