Figure 1.

(A) Arterial PO₂ (mmHg), (B) arterial PCO₂ (mmHg), (C) heart rate (min⁻¹), and (D) mean arterial pressure (mmHg) at baseline (0 min), after pulmonary lavage (5 min), and over the entire observation period (240 min) in rats with mechanical ventilation only (control; n=9), surfactant washout by repeated pulmonary lavage and mechanical ventilation (LAV; n=9), or surfactant washout by repeated pulmonary lavage, mechanical ventilation, and direct stimulation of the AT2 receptor with C21 (0.03 mg/kg body weight; LAV+C21; n=9).

Notes: Data are presented as mean±SD; multivariate nonparametric analysis for longitudinal data over the course of time (two-way MANOVA), p>0.05 for comparison between the LAV and LAV+C21 groups.

Abbreviations: AT2, angiotensin II type 2; C21, Compound 21; MANOVA, multivariate analysis of variance; MAP, mean arterial pressure.