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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2018 May;27(5):525–530. doi: 10.1158/1055-9965.EPI-17-0424

Table 4.

Estimates of colorectal cancer risk associated with metformin use after sulfonylurea use
Antidiabetic drug use Person-Years No. of events Adjusteda
HR (95% CI)
Sulfonlyurea only 80,847.12 167 1.00 (reference)
Sulfonylurea+metformin 58,725.95 122 0.85 (0.65-1.12)
Duration metformin
Never 80,847.12 167 1.00 (reference)
<2.0 years 25,050.73 50 0.93 (0.67-1.29)
2.0 – 4.9 years 20,701.60 44 0.88 (0.60-1.27)
≥5.0 years 12,973.62 28 0.62 (0.38-1.01)
P for trend =0.08