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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Cell Metab. 2018 May 1;27(5):1138–1155.e6. doi: 10.1016/j.cmet.2018.03.015

Figure 1. Annotated schematic for Quantitative Estimation of Endocrine Network Interaction, (QENIE).

Figure 1

A, The basic intuition for our approach is illustrated for 4 strains where adipose tissue expression of Leptin varies in a manner consistent with hypothalamus target genes. When applied to ~100 HMDP strains, this correlation of gene expression is used for cross-tissue predictions. B, This framework was applied to 5 tissues, each examined for gene expression using ~20,000 probes corresponding to ~15,000 genes or RNA-seq in 106 inbred strains of mice. We assigned each axis for every combination of “origin” and “target” tissues. C, Generalized steps for method progression and the application, discussed on greater detail in the main text.