Table 1.

List of compounds exhibiting greater than 60% inhibition of BioA at 100 μg/mL

SN	Compound ID	Structure	NSC ID	Docking score	Percent inhibition at 100 μg/mL	IC50 (μg/mL)*	IC50 (μM)
1	A5		48602	−10.69	77	44.97±0.209	100.48
2	A26		373094	−10.62	65	76.73±2.996	175.58
3	A35		658421	−10.85	85	33.36±1.796	88.16
4	A36		668266	−10.74	82.51	10.48±1.488	28.94
5	A48		106111	−10.53	64	99.10±0.417	273
6	A65		615614	−10.47	84	39.17±3.075	114.42
7	A70		652821	−10.35	74	68.69±3.379	189.5
8	CHM-1				78.73	0.68±0.118	2.42

Notes: Compounds were evaluated for their inhibitory potential at 100 μg/mL and the compounds with greater than 60% inhibition of BioA were further evaluated for the determination of their IC₅₀ values.

^*IC₅₀ values depict the values as the mean ± SD.

Abbreviations: BioA, 7,8-diaminopelargonic acid synthase; SN, serial number; NSC, Cancer Chemotherapy National Service Center number.